爆炸伤
感音神经性聋
医学
立体纤毛(内耳)
螺旋神经节
耳蜗
听力损失
科尔蒂器官
耳鸣
听力学
毛细胞
毒物控制
环境卫生
作者
Takaomi Kurioka,Kunio Mizutari,Katsuki Niwa,Eiko Kimura,Satoko Kawauchi,Yasushi Kobayashi,Shunichi Sato
摘要
The ear is the organ most susceptible to explosion overpressure, and cochlear injuries frequently occur after blast exposure. Blast exposure can lead to sensorineural hearing loss (SNHL), which is an irreversible hearing loss that negatively affects the quality of life. Detailed blast-induced cochlear pathologies, such as the loss of hair cells, spiral ganglion neurons, cochlear synapses, and disruption of stereocilia, have been previously documented. However, determining cochlear sensorineural deterioration after a blast injury is challenging because animals exposed to blast overpressure usually experience tympanic membrane perforation (TMP), which causes concurrent conductive hearing loss. To evaluate pure sensorineural cochlear dysfunction, we developed an experimental animal model of blast-induced cochlear injury using a laser-induced shock wave. This method avoids TMP and concomitant systemic injuries and reproduces the functional decline in the SNHL component in an energy-dependent manner after LISW exposure. This animal model could be a platform for elucidating the pathological mechanisms and exploring potential treatments for blast-induced cochlear dysfunction.
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