鲍曼不动杆菌
替加环素
多粘菌素
抗生素
抗生素耐药性
抗药性
抗菌剂
微生物学
多粘菌素B
多重耐药
医学
生物
重症监护医学
细菌
铜绿假单胞菌
遗传学
作者
Jingchao Shi,Jianghao Cheng,Shourong Liu,Zhu Yufeng,Mingli Zhu
标识
DOI:10.3389/fmicb.2024.1332108
摘要
Acinetobacter baumannii is one of the most common multidrug-resistant pathogens causing nosocomial infections. The prevalence of multidrug-resistant A. baumannii infections is increasing because of several factors, including unregulated antibiotic use. A. baumannii drug resistance rate is high; in particular, its resistance rates for tigecycline and polymyxin—the drugs of last resort for extensively drug-resistant A. baumannii —has been increasing annually. Patients with a severe infection of extensively antibiotic-resistant A. baumannii demonstrate a high mortality rate along with a poor prognosis, which makes treating them challenging. Through carbapenem enzyme production and other relevant mechanisms, A. baumannii has rapidly acquired a strong resistance to carbapenem antibiotics—once considered a class of strong antibacterials for A. baumannii infection treatment. Therefore, understanding the resistance mechanism of A. baumannii is particularly crucial. This review summarizes mechanisms underlying common antimicrobial resistance in A. baumannii , particularly those underlying tigecycline and polymyxin resistance. This review will serve as a reference for reasonable antibiotic use at clinics, as well as new antibiotic development.
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