白色念珠菌
两性霉素B
热带假丝酵母
克鲁斯假丝酵母
假丝酵母病
麦角甾醇
光滑假丝酵母
抗真菌药
抗药性
生物
微生物学
白色体
抗真菌药
抗真菌
生物化学
作者
Lailema Ahmady,Manisha Gothwal,Muhammed Mushthaque Mukkoli,Vinay Kumar Bari
出处
期刊:Apmis
[Wiley]
日期:2024-03-11
卷期号:132 (5): 291-316
被引量:7
摘要
Invasive fungal infections in humans caused by several Candida species, increased considerably in immunocompromised or critically ill patients, resulting in substantial morbidity and mortality. Candida albicans is the most prevalent species, although the frequency of these organisms varies greatly according to geographic region. Infections with C. albicans and non‐albicans Candida species have become more common, especially in the past 20 years, as a result of aging, immunosuppressive medication use, endocrine disorders, malnourishment, extended use of medical equipment, and an increase in immunogenic diseases. Despite C. albicans being the species most frequently associated with human infections, C. glabrata , C. parapsilosis , C. tropicalis , and C. krusei also have been identified. Several antifungal drugs with different modes of action are approved for use in clinical settings to treat fungal infections. However, due to the common eukaryotic structure of humans and fungi, only a limited number of antifungal drugs are available for therapeutic use. Furthermore, drug resistance in Candida species has emerged as a result of the growing use of currently available antifungal drugs against fungal infections. Amphotericin B (AmB), a polyene class of antifungal drugs, is mainly used for the treatment of serious systemic fungal infections. AmB interacts with fungal plasma membrane ergosterol, triggering cellular ion leakage via pore formation, or extracting the ergosterol from the plasma membrane inducing cellular death. AmB resistance is primarily caused by changes in the content or structure of ergosterol. This review summarizes the antifungal drug resistance exhibited by Candida species, with a special focus on AmB.
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