Long‐term neurological dysfunction associated with COVID‐19: Lessons from influenza and inflammatory diseases?

神经病理学 大流行 焦虑 萧条(经济学) 2019年冠状病毒病(COVID-19) 医学 神经科学 炎症 认知 免疫学 重症监护医学 心理学 精神科 疾病 病理 传染病(医学专业) 经济 宏观经济学
作者
Parker Volk,Mohammadreza Rahmani Manesh,Mary Warren,Katie Besko,Elisa Gonçalves de Andrade,Leigh E. Wicki‐Stordeur,Leigh Anne Swayne
出处
期刊:Journal of Neurochemistry [Wiley]
被引量:9
标识
DOI:10.1111/jnc.16016
摘要

Abstract As the COVID‐19 pandemic persists, SARS‐CoV‐2 infection is increasingly associated with long‐term neurological side effects including cognitive impairment, fatigue, depression, and anxiety, colloquially known as “long‐COVID.” While the full extent of long‐COVID neuropathology across years or even decades is not yet known, we can perhaps take direction from long‐standing research into other respiratory diseases, such as influenza, that can present with similar long‐term neurological consequences. In this review, we highlight commonalities in the neurological impacts of influenza and COVID‐19. We first focus on the common potential mechanisms underlying neurological sequelae of long‐COVID and influenza, namely (1) viral neurotropism and (2) dysregulated peripheral inflammation. The latter, namely heightened peripheral inflammation leading to central nervous system dysfunction, is emerging as a shared mechanism in various peripheral inflammatory or inflammation‐associated diseases and conditions. We then discuss historical and modern examples of influenza‐ and COVID‐19‐associated cognitive impairment, depression, anxiety, and fatigue, revealing key similarities in their neurological sequelae. Although we are learning that the effects of influenza and COVID differ somewhat in terms of their influence on the brain, as the impacts of long‐COVID grow, such comparisons will likely prove valuable in guiding ongoing research into long‐COVID, and perhaps foreshadow what could be in store for individuals with COVID‐19 and their brain health.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
AlexLee完成签到,获得积分10
1秒前
枝枝完成签到 ,获得积分10
1秒前
2秒前
黄憨憨发布了新的文献求助10
4秒前
星辰大海应助科研通管家采纳,获得10
4秒前
科研通AI2S应助科研通管家采纳,获得10
4秒前
香蕉觅云应助科研通管家采纳,获得10
4秒前
丘比特应助科研通管家采纳,获得10
4秒前
顾矜应助科研通管家采纳,获得10
5秒前
科研通AI2S应助科研通管家采纳,获得10
5秒前
上官若男应助科研通管家采纳,获得10
5秒前
深情安青应助科研通管家采纳,获得10
5秒前
慕青应助科研通管家采纳,获得10
5秒前
CipherSage应助科研通管家采纳,获得10
5秒前
领导范儿应助科研通管家采纳,获得10
5秒前
5秒前
空山新雨发布了新的文献求助10
6秒前
janarbek给wang的求助进行了留言
6秒前
今后应助搞怪书兰采纳,获得10
13秒前
13秒前
充电宝应助yao采纳,获得10
14秒前
20秒前
21秒前
24秒前
cjy发布了新的文献求助10
26秒前
GYX完成签到 ,获得积分10
26秒前
yao发布了新的文献求助10
27秒前
28秒前
Orange应助重要谷冬采纳,获得10
28秒前
28秒前
29秒前
传奇3应助sje采纳,获得10
29秒前
31秒前
贝贝完成签到,获得积分10
32秒前
哒哒发布了新的文献求助10
33秒前
orixero应助短巷采纳,获得10
34秒前
34秒前
小王同学完成签到 ,获得积分10
35秒前
高分求助中
Sustainability in Tides Chemistry 2800
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Very-high-order BVD Schemes Using β-variable THINC Method 568
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3138630
求助须知:如何正确求助?哪些是违规求助? 2789630
关于积分的说明 7791721
捐赠科研通 2445972
什么是DOI,文献DOI怎么找? 1300801
科研通“疑难数据库(出版商)”最低求助积分说明 626058
版权声明 601079