荟萃分析
幽门螺杆菌
幽门螺杆菌感染
2型糖尿病
医学
联想(心理学)
螺杆菌感染
内科学
糖尿病
心理学
内分泌学
心理治疗师
作者
Walter Chua,Yi‐Kai Hong,Shu-Wei Hu,Hueng-Chuen Fan,Wei‐Hsin Ting
出处
期刊:Medicina
[Universidade de Sao Paulo, Agencia USP de Gestao da Informacao Academica (AGUIA)]
日期:2024-01-09
卷期号:60 (1): 119-119
标识
DOI:10.3390/medicina60010119
摘要
Background and Objectives: Type 1 diabetes mellitus (T1DM) is a chronic and serious condition that is characterized by inadequate pancreatic-β-cells' insulin production. The connection between T1DM and Helicobacter pylori infection remains uncertain. This study aimed to conduct a systematic meta-analysis to examine the association between H. pylori infection, hemoglobin A1c levels, and the development of T1DM. Materials and Methods: The initial search identified 451 articles on the association between H. pylori infection and T1DM. Among them, 12 articles had 2797 participants who met the inclusion criteria for an advanced meta-analysis. Results: A significant association was observed between H. pylori infection and T1DM (OR 1.77, 95% CI 1.47-2.12, p < 0.0001), with heterogeneity: Tau2 = 0.47; Chi2 = 57.07, df = 11 (p < 0.0001); I2 = 81%. Subgroup analysis showed that H. pylori infection was significantly associated with a longer duration of T1DM and higher hemoglobin A1c levels (p < 0.001 for both) but not with age at T1DM diagnosis (p = 0.306). Conclusions: These findings contribute to the understanding of the association between H. pylori infection and T1DM and highlight the potential role of H. pylori in influencing the duration and glycemic control of diabetes. Therefore, pediatric patients who have longstanding T1DM and poor glycemic control should be screened for H. pylori infection.
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