分区(防火)
纳米技术
自组装
功能(生物学)
计算机科学
过程(计算)
生化工程
材料科学
化学
工程类
生物
生物化学
进化生物学
酶
操作系统
作者
Alexey V. Solomonov,Anna Kozell,Ulyana Shimanovich
标识
DOI:10.1002/anie.202318365
摘要
Abstract Protein self‐assembly is a fundamental biological process where proteins spontaneously organize into complex and functional structures without external direction. This process is crucial for the formation of various biological functionalities. However, when protein self‐assembly fails, it can trigger the development of multiple disorders, thus making understanding this phenomenon extremely important. Up until recently, protein self‐assembly has been solely linked either to biological function or malfunction; however, in the past decade or two it has also been found to hold promising potential as an alternative route for fabricating materials for biomedical applications. It is therefore necessary and timely to summarize the key aspects of protein self‐assembly: how the protein structure and self‐assembly conditions (chemical environments, kinetics, and the physicochemical characteristics of protein complexes) can be utilized to design biomaterials. This minireview focuses on the basic concepts of forming supramolecular structures, and the existing routes for modifications. We then compare the applicability of different approaches, including compartmentalization and self‐assembly monitoring. Finally, based on the cutting‐edge progress made during the last years, we summarize the current knowledge about tailoring a final function by introducing changes in self‐assembly and link it to biomaterials’ performance.
科研通智能强力驱动
Strongly Powered by AbleSci AI