免疫原性细胞死亡
胞浆
程序性细胞死亡
活性氧
阿霉素
免疫疗法
声动力疗法
免疫系统
干扰素基因刺激剂
细胞生物学
化学
刺
癌症研究
生物物理学
化疗
生物
生物化学
细胞凋亡
免疫学
遗传学
航空航天工程
工程类
酶
作者
Ye Tian,Hao Tian,Bei Li,Chuanliang Feng,Yunlu Dai
出处
期刊:Small
[Wiley]
日期:2024-01-15
卷期号:20 (26)
被引量:8
标识
DOI:10.1002/smll.202309850
摘要
Abstract Although chemotherapy has the potential to induce tumor immunotherapy via immunogenic cell death (ICD) effects, how to control the intensity of the immune responses still deserves further exploration. Herein, a controllable ultrasound (US)‐triggered chemo‐immunotherapy nanoagonist is successfully synthesized by utilizing the pH and reactive oxygen species (ROS) dual‐responsive PEG‐polyphenol to assemble sonosensitizer zinc oxide (ZnO) and doxorubicin (DOX). The PZnO@DOX nanoparticles have an intelligent disassembly to release DOX and zinc ions in acidic pH conditions. Notably, US irradiation generates ROS by sonodynamic therapy and accelerates the drug release process. Interestingly, after the PZnO@DOX+US treatment, the injured cells release double‐stranded DNA (dsDNA) from the nucleus and mitochondria into the cytosol. Subsequently, both the dsDNA and zinc ions bind with cyclic GMP‐AMP synthase and activate the stimulator of interferon genes (STING) pathway, resulting in the dendritic cell maturation, ultimately promoting DOX‐induced ICD effects and antigen‐specific T cell immunity. Therefore, chemotherapy‐induced immune responses can be modulated by non‐invasive control of US.
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