Abstract In this work, we systematically investigate the two-proton ($2p$) radioactivity assisted by an ultra-intense laser field within a deformed one-parameter model (OPM). The results show that the ultra-intense laser hardly affects the preformation probability of the emitted $2p$-pair, but it can change the $2p$ radioactive half-lives to a finite extent by affecting the penetrability probability. Moreover, we compare the responses of different $2p$ radioactivity nuclei to the laser field, and it is found that the $2p$ radioactivity of nuclei with a low decay width are more easily influenced by the intense laser field. Furthermore, the effects of different physical parameters of a laser pulse on the $2p$ radioactivity were also discussed. The calculations indicate that the lasers characterized by shorter wavelengths and higher intensities exert a more significant influence on the rate of the average change in pulse duration. Finally, we extended the deformed OPM to predict the half-lives of $2p$ radioactivity candidates and identified the possible experimental objects of the laser-assisted $2p$ radioactivity. This study may promote the possibility of future experimental investigations on extensive facilities like GSI and ELI-NP, etc.