环戊烯酮
化学
质子化
催化作用
水解
组合化学
亚胺
药物化学
配体(生物化学)
反应条件
有机化学
受体
生物化学
离子
作者
Ming Dong,Xiaofeng Tong
标识
DOI:10.1021/acs.orglett.3c03999
摘要
A ligand-free Pd(0)-catalyzed cyclization of (Z)-5-iodo-4-pentenenitrile has been realized with the help of HCO2H reductant, which is followed by imine hydrolysis to afford cyclopentenone derivatives in moderate to good yields. Control experiments clearly points out that the proton originally came from HCO2H plays a crucial role on protonation of the resultant imido-Pd2+ intermediate. This protocol features mild condition, operational simplicity, as well as wide functional group tolerance.
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