Multi-level feature extraction and reconstruction for 3D MRI image super-resolution

Magnetic resonance imaging (MRI) is an essential radiology technique in clinical diagnosis, but its spatial resolution may not suffice to meet the growing need for precise diagnosis due to hardware limitations and thicker slice thickness. Therefore, it is crucial to explore suitable methods to increase the resolution of MRI images. Recently, deep learning has yielded many impressive results in MRI image super-resolution (SR) reconstruction. However, current SR networks mainly use convolutions to extract relatively single image features, which may not be optimal for further enhancing the quality of image reconstruction. In this work, we propose a multi-level feature extraction and reconstruction (MFER) method to restore the degraded high-resolution details of MRI images. Specifically, to comprehensively extract different types of features, we design the triple-mixed convolution by leveraging the strengths and uniqueness of different filter operations. For the features of each level, we then apply deconvolutions to upsample them separately at the tail of the network, followed by the feature calibration of spatial and channel attention. Besides, we also use a soft cross-scale residual operation to improve the effectiveness of parameter optimization. Experiments on lesion-free and glioma datasets indicate that our method obtains superior quantitative performance and visual effects when compared with state-of-the-art MRI image SR methods.