EEG spectral and microstate analysis originating residual inhibition of tinnitus induced by tailor-made notched music training

地方政府 脑电图 听力学 心理学 耳鸣 安慰剂 神经科学 医学 替代医学 病理
作者
Min Zhu,Qin Gong
出处
期刊:Frontiers in Neuroscience [Frontiers Media]
卷期号:17 被引量:1
标识
DOI:10.3389/fnins.2023.1254423
摘要

Tailor-made notched music training (TMNMT) is a promising therapy for tinnitus. Residual inhibition (RI) is one of the few interventions that can temporarily inhibit tinnitus, which is a useful technique that can be applied to tinnitus research and explore tinnitus mechanisms. In this study, RI effect of TMNMT in tinnitus was investigated mainly using behavioral tests, EEG spectral and microstate analysis. To our knowledge, this study is the first to investigate RI effect of TMNMT. A total of 44 participants with tinnitus were divided into TMNMT group (22 participants; ECnm, NMnm, RInm represent that EEG recordings with eyes closed stimuli-pre, stimuli-ing, stimuli-post by TMNMT music, respectively) and Placebo control group (22 participants; ECpb, PBpb, RIpb represent that EEG recordings with eyes closed stimuli-pre, stimuli-ing, stimuli-post by Placebo music, respectively) in a single-blind manner. Behavioral tests, EEG spectral analysis (covering delta, theta, alpha, beta, gamma frequency bands) and microstate analysis (involving four microstate classes, A to D) were employed to evaluate RI effect of TMNMT. The results of the study showed that TMNMT had a stronger inhibition ability and longer inhibition time according to the behavioral tests compared to Placebo. Spectral analysis showed that RI effect of TMNMT increased significantly the power spectral density (PSD) of delta, theta bands and decreased significantly the PSD of alpha2 band, and microstate analysis showed that RI effect of TMNMT had shorter duration (microstate B, microstate C), higher Occurrence (microstate A, microstate C, microstate D), Coverage (microstate A) and transition probabilities (microstate A to microstate B, microstate A to microstate D and microstate D to microstate A). Meanwhile, RI effect of Placebo decreased significantly the PSD of alpha2 band, and microstate analysis showed that RI effect of Placebo had shorter duration (microstate C, microstate D), higher occurrence (microstate B, microstate C), lower coverage (microstate C, microstate D), higher transition probabilities (microstate A to microstate B, microstate B to microstate A). It was also found that the intensity of tinnitus symptoms was significant positively correlated with the duration of microstate B in five subgroups (ECnm, NMnm, RInm, ECpb, PBpb). Our study provided valuable experimental evidence and practical applications for the effectiveness of TMNMT as a novel music therapy for tinnitus. The observed stronger residual inhibition (RI) ability of TMNMT supported its potential applications in tinnitus treatment. Furthermore, the temporal dynamics of EEG microstates serve as novel functional and trait markers of synchronous brain activity that contribute to a deep understanding of the neural mechanism underlying TMNMT treatment for tinnitus.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
崔悦欣发布了新的文献求助10
刚刚
希望天下0贩的0应助kk子采纳,获得10
1秒前
丰富的不惜完成签到,获得积分10
3秒前
票子发布了新的文献求助10
3秒前
华仔应助魏莱采纳,获得10
3秒前
F123发布了新的文献求助10
4秒前
shen发布了新的文献求助10
5秒前
5秒前
苗觉觉完成签到,获得积分10
6秒前
帕金森完成签到,获得积分10
7秒前
活力的妙芙完成签到,获得积分10
7秒前
赘婿应助疯子魔煞采纳,获得10
8秒前
橙橙橙完成签到,获得积分10
8秒前
8秒前
你好CDY完成签到,获得积分10
9秒前
9秒前
9秒前
万能图书馆应助希尔伯特采纳,获得10
9秒前
我是老大应助123采纳,获得10
10秒前
芒果小鹌鹑完成签到,获得积分10
11秒前
上官若男应助F123采纳,获得10
12秒前
Singularity应助邢文瑞采纳,获得10
13秒前
c123发布了新的文献求助10
14秒前
嘉嘉琦发布了新的文献求助10
15秒前
wanci应助QWDSA采纳,获得10
17秒前
17秒前
愉快静曼发布了新的文献求助10
20秒前
乐乐乐乐乐乐应助科学家采纳,获得10
21秒前
99完成签到,获得积分10
21秒前
21秒前
友好傲白完成签到,获得积分10
21秒前
FL完成签到 ,获得积分10
22秒前
量子星尘发布了新的文献求助10
23秒前
清新的绿海完成签到,获得积分10
23秒前
山色青完成签到,获得积分10
24秒前
24秒前
ya完成签到,获得积分10
24秒前
等风来完成签到 ,获得积分10
25秒前
疯子魔煞完成签到,获得积分10
25秒前
执着的招牌完成签到,获得积分10
25秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038446
求助须知:如何正确求助?哪些是违规求助? 3576149
关于积分的说明 11374627
捐赠科研通 3305875
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892680
科研通“疑难数据库(出版商)”最低求助积分说明 815048