药代动力学
他克莫司
CYP3A4型
药理学
医学
内科学
移植
细胞色素P450
新陈代谢
作者
Yanping Guan,Xiaolin Liu,Ke Huang,Ying Wang,Kaifeng Qiu,Xueding Wang,Min Huang,Dun‐hua Zhou,Xiaoxia Yu,Guoping Zhong
标识
DOI:10.1016/j.ejps.2024.106839
摘要
Tacrolimus (FK506) is a cornerstone of GVHD-prophylaxis treatment in paediatrics undergoing haematopoietic stem cell transplantation (HSCT). However, due to concerns about highly inter/intra-individual variability, precision dosing of FK506 is crucial. Cytochrome P450 (CYP) 3A4 and 3A5 are considered important sources of FK506 pharmacokinetic variability. Nevertheless, the impact of age-related maturation in hepatic and intestinal CYP3A4/3A5 enzymes remains unknown in paediatric HSCT patients. Physiologically-based pharmacokinetic (PBPK) models were developed and verified in adult volunteers and adult HSCT patients using GastroPlus™
科研通智能强力驱动
Strongly Powered by AbleSci AI