促炎细胞因子
肿瘤坏死因子α
细胞生物学
下调和上调
抑制器
老化
细胞分化
免疫学
癌症研究
生物
化学
炎症
遗传学
癌症
基因
作者
Ming Wang,Yijie Han,Xiaohan Yao,Xixi Duan,Jiajia Wan,Xiaohan Lou,Yan Yan,Peiguo Zheng,Fazhan Wang,Linyu Zhu,Ni Chen,Yanguo Teng,Zihao Wang,Lin Chen,Zhaoqing Wang,Zhihai Qin
出处
期刊:MedComm
[Wiley]
日期:2024-06-01
卷期号:5 (6)
摘要
During the ageing process, TNF-α can promote the expansion of myeloid-derived suppressor cells (MDSCs). However, it remains unclear which receptor(s) of TNF-α are involved in and how they modulate this process. Here, we report that TNFR2 hyperexpression induced by either TNF-α or IL-6, two proinflammatory factors of senescence-associated secretory phenotype (SASP), causes cellular apolarity and differentiation inhibition in aged MDSCs. Ex vivo overexpression of TNFR2 in young MDSCs inhibited their polarity and differentiation, whereas in vivo depletion of
科研通智能强力驱动
Strongly Powered by AbleSci AI