神经保护
神经干细胞
医学
冲程(发动机)
干细胞
间充质干细胞
缺血
移植
自愈水凝胶
牛磺酸
药理学
化学
内科学
细胞生物学
病理
生物
生物化学
氨基酸
机械工程
有机化学
工程类
作者
Zhichao Wang,Chuanzhen Huang,Zhenyu Shi,Hanlian Liu,Xu Han,Zhuang Chen,Shuying Li,Zhen Wang,Jun Huang
出处
期刊:Biomaterials advances
日期:2024-05-21
卷期号:161: 213895-213895
标识
DOI:10.1016/j.bioadv.2024.213895
摘要
Ischemic stroke, a cerebrovascular disease caused by arterial occlusion in the brain, can lead to brain impairment and even death. Stem cell therapies have shown positive advantages to treat ischemic stroke because of their extended time window, but the cell viability is poor when transplanted into the brain directly. Therefore, a new hydrogel GelMA-T was developed by introducing taurine on GelMA to transplant neural stem cells. The GelMA-T displayed the desired photocuring ability, micropore structure, and cytocompatibility. Its compressive modulus was more similar to neural tissue compared to that of GelMA. The GelMA-T could protect SH-SY5Y cells from injury induced by OGD/R. Furthermore, the NE-4C cells showed better proliferation performance in GelMA-T than that in GelMA during both 2D and 3D cultures. All results demonstrate that GelMA-T possesses a neuroprotective effect for ischemia/reperfusion injury against ischemic stroke and plays a positive role in promoting NSC proliferation. The novel hydrogel is anticipated to function as cell vehicles for the transplantation of neural stem cells into the stroke cavity, aiming to treat ischemic stroke.
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