尼古丁
金黄色葡萄球菌
骨髓炎
体内
微生物学
抗生素
化学
生物
药理学
细菌
免疫学
生物技术
遗传学
神经科学
作者
Xuyou Zhou,Sushuang Ma,Yingjie Xu,Chun Sun,Jianyun Liao,Mingrui Song,Guanzhi Li,Liu Yuchen,Peng Chen,Yanjun Hu,Yutian Wang,Bin Yu
标识
DOI:10.1016/j.intimp.2024.112223
摘要
Although smoking is a significant risk factor for osteomyelitis, there is limited experimental evidence that nicotine, a key tobacco constituent, is associated with this condition, leaving its mechanistic implications uncharacterized. This study revealed that nicotine promotes Staphylococcus aureus-induced osteomyelitis by increasing Nrf2 and Slc7a11 expression in vivo and in vitro. Inhibition of Slc7a11 using Erastin augmented bacterial phagocytosis/killing capabilities and fortified antimicrobial responses in an osteomyelitis model. Moreover, untargeted metabolomic analysis demonstrated that Erastin mitigated the effects of nicotine on S. aureus-induced osteomyelitis by altering glutamate/glutathione metabolism. These findings suggest that nicotine aggravates S. aureus-induced osteomyelitis by activating the Nrf2/Slc7a11 signaling pathway and that Slc7a11 inhibition can counteract the detrimental health effects of nicotine.
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