先天性淋巴细胞
生物
免疫系统
免疫学
细胞因子
关贸总协定3
细胞生物学
获得性免疫系统
转录因子
免疫
炎症
遗传学
基因
作者
Aydan C. H. Szeto,Paula A. Clark,Ana C. F. Ferreira,Morgan W. D. Heycock,Eric Griffiths,Eric Jou,Jonathan Mannion,Shi-Lu Luan,Sophie Storrar,Martin Knolle,Patrycja Kozik,Helen E. Jolin,Padraic G. Fallon,Andrew N. J. McKenzie
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-06-28
卷期号:384 (6703)
被引量:1
标识
DOI:10.1126/science.adl0370
摘要
Innate lymphoid cells (ILCs) and adaptive T lymphocytes promote tissue homeostasis and protective immune responses. Their production depends on the transcription factor GATA3, which is further elevated specifically in ILC2s and T helper 2 cells to drive type-2 immunity during tissue repair, allergic disorders, and anti-helminth immunity. The control of this crucial up-regulation is poorly understood. Using CRISPR screens in ILCs we identified previously unappreciated myocyte-specific enhancer factor 2d (Mef2d)-mediated regulation of GATA3-dependent type-2 lymphocyte differentiation. Mef2d-deletion from ILC2s and/or T cells specifically protected against an allergen lung challenge. Mef2d repressed Regnase-1 endonuclease expression to enhance IL-33 receptor production and IL-33 signaling and acted downstream of calcium-mediated signaling to translocate NFAT1 to the nucleus to promote type-2 cytokine-mediated immunity.
科研通智能强力驱动
Strongly Powered by AbleSci AI