代谢组学
浆液性液体
输卵管
去甲肾上腺素
浆液性卵巢癌
内科学
卵巢癌
内分泌学
医学
生物
病理
生物信息学
妇科
癌症
多巴胺
作者
Tova M. Bergsten,Hannah Lusk,Monica A. Haughan,Jason A. Guerrero,Sarah E. Levy,Daniel D. Lantvit,Laura M. Sanchez,Joanna E. Burdette
出处
期刊:ACS pharmacology & translational science
[American Chemical Society]
日期:2024-06-30
标识
DOI:10.1021/acsptsci.4c00238
摘要
High-grade serous ovarian cancer is the most common and lethal gynecologic malignancy, which is often attributed to the lack of available screenings, allowing the disease to progress unnoticed until it is diagnosed at more aggressive stages. As such, identifying signals in the tumor microenvironment involved in the primary metastasis of tumorigenic fallopian tube epithelial (FTE) cells to the ovary could provide new avenues for prevention, diagnostics, or therapeutic intervention. Since our previous work identified that the interaction of tumorigenic FTE and the ovary causes the release of norepinephrine (NE) from the ovary, we intended to determine the effects of ovarian NE on signaling and invasion of tumorigenic FTE models and high-grade serous ovarian cancer cell lines. We demonstrate that NE does not universally enhance migration, invasion, or adhesion by using multiple cell types but does alter specific oncogenic protein expression in certain models.
科研通智能强力驱动
Strongly Powered by AbleSci AI