A NIR‐II‐Emissive Organic Nanomedicine with Biomimetic Engineering for High‐Contrast Targeted Bioimaging and Multiple Phototherapies of Pancreatic Tumors

Abstract Recent advances are achieved in the design and development of efficient organic photosensitizers (PSs), especially with fluorescence imaging navigation in the second near‐infrared (NIR‐II, 1000–1700 nm) region. However, there are simply a handful of NIR‐II emissive organic PSs with efficient oxygen‐independent capability due to the scarcity of high‐performance NIR‐responsive organic materials and targeted delivery. Herein, a NIR‐II‐emissive organic nanomedicine with biomimetic engineering for high‐performance NIR‐II imaging and targeted multiple phototherapies of pancreatic tumors is reported. An A‐D‐A‐type conjugated small‐molecule TPC is designed and used to prepare water‐dispersive nanoparticles, which demonstrated high efficiency for type I and type II photodynamic performances, good photothermal conversion of 57%, and bright NIR‐II emission with a quantum yield of 9.8% under 808 nm light irradiation. With pancreatic cancer cell membrane camouflage, the biomimetic TPC nanomedicine achieved high‐resolution and targeted bioimaging of whole‐body blood vessels and tumors. Antitumor experiments demonstrated the high efficiency of the biomimetic TPC nanomedicine for pancreatic tumor elimination and good biosafety with 808 nm light irradiation. This work demonstrated a NIR‐II‐emissive versatile nanomedicine with enhanced tumor‐targeting for high‐resolution NIR‐II bioimaging and superior phototheranostics, providing a feasible idea for the evolution of targeted and high‐performance theranostics.