炎症
荧光
亚硫酸盐
线粒体
粘度
生物物理学
化学
纳米技术
细胞生物学
材料科学
生物化学
生物
物理
免疫学
光学
复合材料
作者
Feiyi Wang,Dan Zhang,Hang Yang,Zhe Zhou,Feiyi Wang,Zhao Wang,Jun Ren,Erfei Wang
出处
期刊:Analyst
[The Royal Society of Chemistry]
日期:2024-01-01
被引量:1
摘要
Many diseases in the human body are related to the overexpression of viscosity and sulfur dioxide. Therefore, it is essential to develop rapid and sensitive fluorescent probes to detect viscosity and sulfur dioxide. In the present work, we developed a dual-response fluorescent probe (ES) for efficient detection of viscosity and sulfur dioxide while targeting mitochondria well. The probe generates intramolecular charge transfer by pushing and pulling the electron-electron system, and the ICT effect is destroyed and the fluorescence quenched upon reaction with sulfite. The rotation of the molecule is inhibited in the high-viscosity system, producing a bright red light. In addition, the probe has good biocompatibility and can be used to detect sulfite in cells, zebrafish and mice, as well as upregulation of viscosity in LPS-induced inflammation models. We expect that the dual response fluorescent probe ES will be able to detect viscosity and sulfite efficiently, providing an effective means of detecting viscosity and sulfite-related diseases.
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