阿比坦
二萜
萜类
化学
立体化学
二维核磁共振波谱
胡杨
绝对构型
生药学
有机化学
生物活性
植物
生物
生物化学
体外
作者
Lina Huang,Yunyun Liu,Hong‐Bin Fang,Ya‐Bin Jiao,Yong‐Xian Cheng
出处
期刊:Fitoterapia
[Elsevier]
日期:2023-05-17
卷期号:168: 105545-105545
被引量:5
标识
DOI:10.1016/j.fitote.2023.105545
摘要
Six new diterpenoids, identified as two abietane derivatives, euphraticanoids J and K (1 and 2), two pimarane derivatives, euphraticanoids L and M (3 and 4), and two 9,10-seco-abietane derivatives, euphraticanoids N and O (5 and 6) were isolated from Populus euphratica resins. Their structures including absolute configurations were characterized using spectroscopic, quantum chemical NMR, and ECD calculation methods. The anti-inflammatory activity of the compounds was tested and the results revealed that compounds 4 and 6 inhibited the production of iNOS and COX-2 in a dose-dependent manner in lipopolysaccharide (LPS)-induced RAW 264.7 cells.
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