TLR7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension

Tweetable abstract

This study introduced a combination of autoimmune stimuli (TLR-7/8 agonist) and endothelial injury (Sugen) and established a novel rat model representing immune–vascular pathological events mimicking human PAH associated with autoimmune disordershttps://bit.ly/3P3H5V0