环肽
药物发现
生物信息学
计算生物学
化学
噬菌体展示
英特因
肽
肽库
纳米技术
生物化学
生物
肽序列
材料科学
基因
核糖核酸
RNA剪接
作者
Xinting Li,Timothy W. Craven,Paul M. Levine
标识
DOI:10.1021/acs.jmedchem.2c01077
摘要
Cyclic peptides are among the most diverse architectures for current drug discovery efforts. Their size, stability, and ease of synthesis provide attractive scaffolds to engage and modulate some of the most challenging targets, including protein–protein interactions and those considered to be "undruggable". With a variety of sophisticated screening technologies to produce libraries of cyclic peptides, including phage display, mRNA display, split intein circular ligation of peptides, and in silico screening, a new era of cyclic peptide drug discovery is at the forefront of modern medicine. In this perspective, we begin by discussing cyclic peptides approved for clinical use in the past two decades. Particular focus is placed around synthetic chemistries to generate de novo libraries of cyclic peptides and novel methods to screen them. The perspective culminates with future prospects for generating cyclic peptides as viable therapeutic options and discusses the advantages and disadvantages currently being faced with bringing them to market.
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