Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood

后代 人口学 队列 体质指数 卵胞浆内精子注射 人口 医学 队列研究 辅助生殖技术 怀孕 体外受精 生物 不育 内分泌学 内科学 遗传学 社会学
作者
Ahmed Elhakeem,Amy E Taylor,Hazel Inskip,Jonathan Huang,Muriel Tafflet,Johan L. Vinther,Federica Asta,Jan S. Erkamp,Luigi Gagliardi,Kathrin Guerlich,Jane Halliday,Margreet W Harskamp-van Ginkel,Jianxing He,Vincent W. V. Jaddoe,Sharon Lewis,Gillian M. Maher,Yannis Μanios,Toby Mansell,Fergus P. McCarthy,Sheila McDonald,Emanuela Medda,Lorenza Nisticò,Angela Pinot de Moira,Maja Popović,Irwin Reiss,Carina Rodrigues,Theodosia Salika,Ash Smith,Maria Antonietta Stazi,Caroline Walker,Muci Wu,Bjørn Olav Åsvold,Henrique Barros,Sonia Brescianini,David Burgner,Jerry Ky Chan,Marie‐Aline Charles,Johan G. Eriksson,Romy Gaillard,Veit Grote,Siri Eldevik Håberg,Barbara Heude,Berthold Koletzko,Sarah Morton,George Moschonis,Deirdre M. Murray,Desmond O'Mahony,Daniela Porta,Xiu Qiu,Lorenzo Richiardi,Franca Rusconi,Richard Saffery,Suzanne Tough,Tanja G. M. Vrijkotte,Scott M. Nelson,Anne‐Marie Nybo Andersen,Maria C Magnus,Deborah A Lawlor
出处
期刊:JAMA network open [American Medical Association]
卷期号:5 (7): e2222106-e2222106 被引量:10
标识
DOI:10.1001/jamanetworkopen.2022.22106
摘要

People conceived using assisted reproductive technology (ART) make up an increasing proportion of the world's population.To investigate the association of ART conception with offspring growth and adiposity from infancy to early adulthood in a large multicohort study.This cohort study used a prespecified coordinated analysis across 26 European, Asia-Pacific, and North American population-based cohort studies that included people born between 1984 and 2018, with mean ages at assessment of growth and adiposity outcomes from 0.6 months to 27.4 years. Data were analyzed between November 2019 and February 2022.Conception by ART (mostly in vitro fertilization, intracytoplasmic sperm injection, and embryo transfer) vs natural conception (NC; without any medically assisted reproduction).The main outcomes were length / height, weight, and body mass index (BMI; calculated as weight in kilograms divided by height in meters squared). Each cohort was analyzed separately with adjustment for maternal BMI, age, smoking, education, parity, and ethnicity and offspring sex and age. Results were combined in random effects meta-analysis for 13 age groups.Up to 158 066 offspring (4329 conceived by ART) were included in each age-group meta-analysis, with between 47.6% to 60.6% females in each cohort. Compared with offspring who were NC, offspring conceived via ART were shorter, lighter, and thinner from infancy to early adolescence, with differences largest at the youngest ages and attenuating with older child age. For example, adjusted mean differences in offspring weight were -0.27 (95% CI, -0.39 to -0.16) SD units at age younger than 3 months, -0.16 (95% CI, -0.22 to -0.09) SD units at age 17 to 23 months, -0.07 (95% CI, -0.10 to -0.04) SD units at age 6 to 9 years, and -0.02 (95% CI, -0.15 to 0.12) SD units at age 14 to 17 years. Smaller offspring size was limited to individuals conceived by fresh but not frozen embryo transfer compared with those who were NC (eg, difference in weight at age 4 to 5 years was -0.14 [95% CI, -0.20 to -0.07] SD units for fresh embryo transfer vs NC and 0.00 [95% CI, -0.15 to 0.15] SD units for frozen embryo transfer vs NC). More marked differences were seen for body fat measurements, and there was imprecise evidence that offspring conceived by ART developed greater adiposity by early adulthood (eg, ART vs NC difference in fat mass index at age older than 17 years: 0.23 [95% CI, -0.04 to 0.50] SD units).These findings suggest that people conceiving or conceived by ART can be reassured that differences in early growth and adiposity are small and no longer evident by late adolescence.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
klaydid完成签到,获得积分10
刚刚
刚刚
爱学习发布了新的文献求助10
1秒前
1秒前
新新完成签到 ,获得积分10
2秒前
Eric完成签到,获得积分10
2秒前
2秒前
3秒前
领导范儿应助蒋j采纳,获得10
3秒前
西瓜完成签到,获得积分10
4秒前
5秒前
5秒前
刘莅完成签到 ,获得积分10
6秒前
糖果风发布了新的文献求助10
6秒前
薰硝壤应助TearMarks采纳,获得10
6秒前
Adel发布了新的文献求助10
6秒前
cc发布了新的文献求助10
7秒前
蒋j完成签到,获得积分10
7秒前
waa完成签到,获得积分10
8秒前
8秒前
言叶发布了新的文献求助10
10秒前
深情安青应助然后先生采纳,获得10
10秒前
文人青发布了新的文献求助10
11秒前
爱静静应助EVEN采纳,获得10
12秒前
思源应助小王采纳,获得10
12秒前
我是老大应助糖果风采纳,获得10
13秒前
16秒前
吴明轩完成签到,获得积分10
16秒前
orixero应助背后飞松采纳,获得10
18秒前
18秒前
wen完成签到 ,获得积分10
19秒前
19秒前
wandong完成签到,获得积分10
20秒前
22秒前
小王发布了新的文献求助10
23秒前
24秒前
大个应助雷大帅采纳,获得10
25秒前
28秒前
28秒前
30秒前
高分求助中
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3182225
求助须知:如何正确求助?哪些是违规求助? 2832577
关于积分的说明 7989817
捐赠科研通 2494603
什么是DOI,文献DOI怎么找? 1330858
科研通“疑难数据库(出版商)”最低求助积分说明 636156
邀请新用户注册赠送积分活动 603070