Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood

后代 人口学 队列 体质指数 卵胞浆内精子注射 人口 医学 队列研究 辅助生殖技术 怀孕 体外受精 生物 不育 内分泌学 内科学 遗传学 社会学
作者
Ahmed Elhakeem,Amy E Taylor,Hazel Inskip,Jonathan Huang,Muriel Tafflet,Johan L. Vinther,Federica Asta,Jan S. Erkamp,Luigi Gagliardi,Kathrin Guerlich,Jane Halliday,Margreet W Harskamp-van Ginkel,Jianxing He,Vincent W. V. Jaddoe,Sharon Lewis,Gillian M. Maher,Yannis Μanios,Toby Mansell,Fergus P. McCarthy,Sheila McDonald,Emanuela Medda,Lorenza Nisticò,Angela Pinot de Moira,Maja Popović,Irwin Reiss,Carina Rodrigues,Theodosia Salika,Ash Smith,Maria Antonietta Stazi,Caroline Walker,Muci Wu,Bjørn Olav Åsvold,Henrique Barros,Sonia Brescianini,David Burgner,Jerry Ky Chan,Marie‐Aline Charles,Johan G. Eriksson,Romy Gaillard,Veit Grote,Siri Eldevik Håberg,Barbara Heude,Berthold Koletzko,Sarah Morton,George Moschonis,Deirdre M. Murray,Desmond O'Mahony,Daniela Porta,Xiu Qiu,Lorenzo Richiardi,Franca Rusconi,Richard Saffery,Suzanne Tough,Tanja G. M. Vrijkotte,Scott M. Nelson,Anne‐Marie Nybo Andersen,Maria C Magnus,Deborah A Lawlor
出处
期刊:JAMA network open [American Medical Association]
卷期号:5 (7): e2222106-e2222106 被引量:10
标识
DOI:10.1001/jamanetworkopen.2022.22106
摘要

People conceived using assisted reproductive technology (ART) make up an increasing proportion of the world's population.To investigate the association of ART conception with offspring growth and adiposity from infancy to early adulthood in a large multicohort study.This cohort study used a prespecified coordinated analysis across 26 European, Asia-Pacific, and North American population-based cohort studies that included people born between 1984 and 2018, with mean ages at assessment of growth and adiposity outcomes from 0.6 months to 27.4 years. Data were analyzed between November 2019 and February 2022.Conception by ART (mostly in vitro fertilization, intracytoplasmic sperm injection, and embryo transfer) vs natural conception (NC; without any medically assisted reproduction).The main outcomes were length / height, weight, and body mass index (BMI; calculated as weight in kilograms divided by height in meters squared). Each cohort was analyzed separately with adjustment for maternal BMI, age, smoking, education, parity, and ethnicity and offspring sex and age. Results were combined in random effects meta-analysis for 13 age groups.Up to 158 066 offspring (4329 conceived by ART) were included in each age-group meta-analysis, with between 47.6% to 60.6% females in each cohort. Compared with offspring who were NC, offspring conceived via ART were shorter, lighter, and thinner from infancy to early adolescence, with differences largest at the youngest ages and attenuating with older child age. For example, adjusted mean differences in offspring weight were -0.27 (95% CI, -0.39 to -0.16) SD units at age younger than 3 months, -0.16 (95% CI, -0.22 to -0.09) SD units at age 17 to 23 months, -0.07 (95% CI, -0.10 to -0.04) SD units at age 6 to 9 years, and -0.02 (95% CI, -0.15 to 0.12) SD units at age 14 to 17 years. Smaller offspring size was limited to individuals conceived by fresh but not frozen embryo transfer compared with those who were NC (eg, difference in weight at age 4 to 5 years was -0.14 [95% CI, -0.20 to -0.07] SD units for fresh embryo transfer vs NC and 0.00 [95% CI, -0.15 to 0.15] SD units for frozen embryo transfer vs NC). More marked differences were seen for body fat measurements, and there was imprecise evidence that offspring conceived by ART developed greater adiposity by early adulthood (eg, ART vs NC difference in fat mass index at age older than 17 years: 0.23 [95% CI, -0.04 to 0.50] SD units).These findings suggest that people conceiving or conceived by ART can be reassured that differences in early growth and adiposity are small and no longer evident by late adolescence.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
dasdsa发布了新的文献求助10
1秒前
芝士球球应助fifteen采纳,获得10
2秒前
森森完成签到,获得积分10
2秒前
2秒前
Arwen完成签到,获得积分10
3秒前
CipherSage应助xinxi采纳,获得30
4秒前
Evangeline完成签到,获得积分10
6秒前
hushan53发布了新的文献求助10
6秒前
aaha完成签到,获得积分10
6秒前
卷卷酱完成签到,获得积分10
8秒前
yyhatb发布了新的文献求助10
9秒前
Ava应助gggyyy采纳,获得10
9秒前
大气的远望完成签到,获得积分10
10秒前
希望天下0贩的0应助博宇采纳,获得10
10秒前
HeyHsc完成签到 ,获得积分10
11秒前
小兔牙大脸猫完成签到,获得积分20
12秒前
Evangeline发布了新的文献求助10
13秒前
小马甲应助djx123采纳,获得10
14秒前
没想好名字应助brucezheng采纳,获得10
16秒前
科研通AI2S应助vickyyao采纳,获得10
16秒前
Maksim发布了新的文献求助20
16秒前
Zhou发布了新的文献求助10
17秒前
唐不空发布了新的文献求助10
18秒前
19秒前
酷波er应助小晟采纳,获得10
19秒前
Tonald Yang发布了新的文献求助10
20秒前
Yu发布了新的文献求助30
20秒前
杭ge给杭ge的求助进行了留言
21秒前
森森发布了新的文献求助30
21秒前
刻苦以寒完成签到,获得积分10
21秒前
22秒前
23秒前
xuzhu0907完成签到,获得积分10
24秒前
庶民文献发布了新的文献求助10
25秒前
科目三应助ty-采纳,获得10
26秒前
djx123发布了新的文献求助10
28秒前
阔达白筠发布了新的文献求助10
28秒前
29秒前
JackMa应助hushan53采纳,获得10
30秒前
30秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3188478
求助须知:如何正确求助?哪些是违规求助? 2837934
关于积分的说明 8017894
捐赠科研通 2500657
什么是DOI,文献DOI怎么找? 1335064
科研通“疑难数据库(出版商)”最低求助积分说明 637466
邀请新用户注册赠送积分活动 605496