亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood

后代 人口学 队列 体质指数 卵胞浆内精子注射 人口 医学 队列研究 辅助生殖技术 怀孕 体外受精 生物 不育 内分泌学 内科学 遗传学 社会学
作者
Ahmed Elhakeem,Amy E Taylor,Hazel Inskip,Jonathan Huang,Muriel Tafflet,Johan L. Vinther,Federica Asta,Jan S. Erkamp,Luigi Gagliardi,Kathrin Guerlich,Jane Halliday,Margreet W Harskamp-van Ginkel,Jianxing He,Vincent W. V. Jaddoe,Sharon Lewis,Gillian M. Maher,Yannis Μanios,Toby Mansell,Fergus P. McCarthy,Sheila McDonald,Emanuela Medda,Lorenza Nisticò,Angela Pinot de Moira,Maja Popović,Irwin Reiss,Carina Rodrigues,Theodosia Salika,Ash Smith,Maria Antonietta Stazi,Caroline Walker,Muci Wu,Bjørn Olav Åsvold,Henrique Barros,Sonia Brescianini,David Burgner,Jerry Ky Chan,Marie‐Aline Charles,Johan G. Eriksson,Romy Gaillard,Veit Grote,Siri Eldevik Håberg,Barbara Heude,Berthold Koletzko,Sarah Morton,George Moschonis,Deirdre M. Murray,Desmond O'Mahony,Daniela Porta,Xiu Qiu,Lorenzo Richiardi,Franca Rusconi,Richard Saffery,Suzanne Tough,Tanja G. M. Vrijkotte,Scott M. Nelson,Anne‐Marie Nybo Andersen,Maria C Magnus,Deborah A Lawlor
出处
期刊:JAMA network open [American Medical Association]
卷期号:5 (7): e2222106-e2222106 被引量:10
标识
DOI:10.1001/jamanetworkopen.2022.22106
摘要

People conceived using assisted reproductive technology (ART) make up an increasing proportion of the world's population.To investigate the association of ART conception with offspring growth and adiposity from infancy to early adulthood in a large multicohort study.This cohort study used a prespecified coordinated analysis across 26 European, Asia-Pacific, and North American population-based cohort studies that included people born between 1984 and 2018, with mean ages at assessment of growth and adiposity outcomes from 0.6 months to 27.4 years. Data were analyzed between November 2019 and February 2022.Conception by ART (mostly in vitro fertilization, intracytoplasmic sperm injection, and embryo transfer) vs natural conception (NC; without any medically assisted reproduction).The main outcomes were length / height, weight, and body mass index (BMI; calculated as weight in kilograms divided by height in meters squared). Each cohort was analyzed separately with adjustment for maternal BMI, age, smoking, education, parity, and ethnicity and offspring sex and age. Results were combined in random effects meta-analysis for 13 age groups.Up to 158 066 offspring (4329 conceived by ART) were included in each age-group meta-analysis, with between 47.6% to 60.6% females in each cohort. Compared with offspring who were NC, offspring conceived via ART were shorter, lighter, and thinner from infancy to early adolescence, with differences largest at the youngest ages and attenuating with older child age. For example, adjusted mean differences in offspring weight were -0.27 (95% CI, -0.39 to -0.16) SD units at age younger than 3 months, -0.16 (95% CI, -0.22 to -0.09) SD units at age 17 to 23 months, -0.07 (95% CI, -0.10 to -0.04) SD units at age 6 to 9 years, and -0.02 (95% CI, -0.15 to 0.12) SD units at age 14 to 17 years. Smaller offspring size was limited to individuals conceived by fresh but not frozen embryo transfer compared with those who were NC (eg, difference in weight at age 4 to 5 years was -0.14 [95% CI, -0.20 to -0.07] SD units for fresh embryo transfer vs NC and 0.00 [95% CI, -0.15 to 0.15] SD units for frozen embryo transfer vs NC). More marked differences were seen for body fat measurements, and there was imprecise evidence that offspring conceived by ART developed greater adiposity by early adulthood (eg, ART vs NC difference in fat mass index at age older than 17 years: 0.23 [95% CI, -0.04 to 0.50] SD units).These findings suggest that people conceiving or conceived by ART can be reassured that differences in early growth and adiposity are small and no longer evident by late adolescence.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
15秒前
42秒前
zhuzhu007发布了新的文献求助10
46秒前
Yucorn完成签到 ,获得积分10
54秒前
1分钟前
1分钟前
jingjing发布了新的文献求助10
2分钟前
2分钟前
2分钟前
feiying发布了新的文献求助10
3分钟前
爱静静完成签到,获得积分0
3分钟前
3分钟前
科研界的滂菜完成签到,获得积分10
3分钟前
斯文败类应助feiying采纳,获得10
3分钟前
林非鹿完成签到,获得积分10
3分钟前
feiying完成签到,获得积分10
3分钟前
jasmine完成签到 ,获得积分10
4分钟前
tufei完成签到,获得积分10
4分钟前
逝月完成签到,获得积分10
5分钟前
7分钟前
lovelife完成签到,获得积分10
7分钟前
7分钟前
yiyiyiyiyi//完成签到,获得积分10
7分钟前
顾矜应助科研通管家采纳,获得10
8分钟前
9分钟前
申木完成签到 ,获得积分10
10分钟前
zokor完成签到 ,获得积分10
10分钟前
Jasper应助夏天的蜜雪冰城采纳,获得10
10分钟前
puzhongjiMiQ发布了新的文献求助10
10分钟前
puzhongjiMiQ完成签到,获得积分10
11分钟前
吱吱草莓派完成签到 ,获得积分10
11分钟前
11分钟前
欣喜翠丝发布了新的文献求助10
11分钟前
lyyzxx完成签到 ,获得积分10
12分钟前
土书发布了新的文献求助10
12分钟前
13分钟前
zai完成签到 ,获得积分10
13分钟前
13分钟前
土书完成签到,获得积分10
13分钟前
欣喜翠丝完成签到,获得积分20
13分钟前
高分求助中
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
A prescription for engineering PFAS biodegradation 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3183723
求助须知:如何正确求助?哪些是违规求助? 2833759
关于积分的说明 7995498
捐赠科研通 2496028
什么是DOI,文献DOI怎么找? 1331823
科研通“疑难数据库(出版商)”最低求助积分说明 636435
邀请新用户注册赠送积分活动 603609