A triple cascade approach towards the diastereoselective synthesis of spiro trans-decalinol scaffolds

Multisubstituted spiro trans -decalinol scaffolds can be synthesized using readily accessible cyclohexanone and β-nitrostyrene with 2-arylidene-1,3-indanedione with a good yield (up to 75%) and high diastereoselectivity (>20 : 1) via (2+2+2) cyclization.