纳米载体
生物利用度
杨梅素
类黄酮
槲皮素
柚皮素
化学
固体脂质纳米粒
药理学
纳米颗粒
胶束
体内
抗氧化剂
纳米技术
生物化学
材料科学
医学
生物
生物技术
有机化学
山奈酚
水溶液
作者
Subhajit Maity,Arghya Acharyya,Abhay Sankar Chakraborti
标识
DOI:10.1016/j.eurpolymj.2022.111455
摘要
Flavonoids are a ubiquitous group of plant metabolites, which exhibit therapeutic potential like anticarcinogenic and antidiabetic activities through various cellular signaling pathways via their antioxidant properties. However, beneficial medicinal properties of the flavonoids are inhibited due to their rapid metabolism, poor absorption, and low water solubilities. Nanocarriers have a huge potentiality to improve bioavailability of dietary flavonoids. Here we have reviewed the studies on the antidiabetic and anticancer activities of the flavonoids namely, quercetin, naringenin and myricetin, using different nanoparticle-based delivery systems. Nanoparticles mainly include polymeric, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), micelles, liposomes, nanosuspensions and nanoemulsions. Wide range of studies including ex vivo, in vitro, and in vivo systems suggest that flavonoid-nanoparticle formulations have better therapeutic potential for the treatment of diseases like cancer and diabetes.
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