Asymmetric cascades of the π-allyl complex: a journey from transition-metal catalysis to metallaphotocatalysis

The enantioselective catalytic cascade involving Tsuji-Trost allylation has provided a viable strategy for the construction of multiple asymmetric C-C and C-X centres and numerous methods have been developed around it for the synthesis of various vital scaffolds. The synthetic utility of this strategy was enhanced by replacing the customary allyl acetates with ethylene diacetates/dicarbonates, vinyl epoxides, vinyl oxetanes, vinyl ethylene carbonates, vinyl cyclopropanes, enynes, and dienes using transition-metal catalysis. One more milestone was achieved when metallaphotocatalysis provided the necessary platform for these cascades by using a cheaper metal. This review will provide a summary of these enantioselective catalytic cascades from 2015.