材料科学
有机半导体
光敏性
半导体
异质结
光强度
光化学
光电子学
纳米技术
化学
光学
物理
作者
Achilleas Savva,Adel Hama,Gabriel Herrera‐López,Tony Schmidt,Ludovico Migliaccio,Nadia Yousfi Steiner,Malak Kawan,Hubert Fiumelli,Pierre J. Magistretti,Iain McCulloch,Derya Baran,Nicola Gasparini,Rainer Schindl,Eric Daniel Głowacki,Sahika Inal
标识
DOI:10.1002/advs.202300473
摘要
Abstract Recent advances in light‐responsive materials enabled the development of devices that can wirelessly activate tissue with light. Here it is shown that solution‐processed organic heterojunctions can stimulate the activity of primary neurons at low intensities of light via photochemical reactions. The p‐type semiconducting polymer PDCBT and the n‐type semiconducting small molecule ITIC (a non‐fullerene acceptor) are coated on glass supports, forming a p – n junction with high photosensitivity. Patch clamp measurements show that low‐intensity white light is converted into a cue that triggers action potentials in primary cortical neurons. The study shows that neat organic semiconducting p – n bilayers can exchange photogenerated charges with oxygen and other chemical compounds in cell culture conditions. Through several controlled experimental conditions, photo‐capacitive, photo‐thermal, and direct hydrogen peroxide effects on neural function are excluded, with photochemical delivery being the possible mechanism. The profound advantages of low‐intensity photo‐chemical intervention with neuron electrophysiology pave the way for developing wireless light‐based therapy based on emerging organic semiconductors.
科研通智能强力驱动
Strongly Powered by AbleSci AI