Differences in the prevalence of uveitis between Crohn's disease and ulcerative colitis: A systematic review and meta‐analysis

医学 葡萄膜炎 溃疡性结肠炎 优势比 荟萃分析 炎症性肠病 内科学 置信区间 入射(几何) 相对风险 子群分析 克罗恩病 疾病 胃肠病学 免疫学 物理 光学
作者
Haowen Lin,Jiaqing Zhang,Liang Chen,Dongxuan Wu,Yuan Tan,Lixia Luo,Zhenzhen Liu
出处
期刊:Acta Ophthalmologica [Wiley]
卷期号:102 (4) 被引量:5
标识
DOI:10.1111/aos.15793
摘要

Abstract Purpose Uveitis is one of the ocular manifestations of inflammatory bowel disease (IBD) that is often overlooked and has been considered a sign of severe IBD. As typical subtypes of IBD, differences exist in the prevalence of uveitis between Crohn's disease (CD) and ulcerative colitis (UC). Our study systematically assessed differences in the prevalence of uveitis between CD and UC. Methods The Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) guidelines were used. We performed a systematic review of published literature from PubMed and Embase on 30 March 2022. Two investigators independently selected studies, extracted data and evaluated methodological quality. Either a fixed‐ or a random‐effects model was used to calculate the risk ratio (RR), odds ratio (OR) and 95% confidence interval (95% CI) depending on the heterogeneity of studies. Sensitivity analysis was used to examine the heterogeneity by removing article by article, while subgroup analysis was conducted in accordance with various regions. Results Our study included data from 14 studies encompassing 115 854 participants. The prevalence of uveitis in IBD was estimated to be 2.38% (95% CI 1.60%–3.17%). The prevalence of uveitis in CD (3.27%, 95% CI 2.15%–4.39%) was significantly higher than in UC (1.60%, 95% CI 0.93%–2.27%; RR 1.76, 95% CI 1.39–2.22, p < 0.05). In subgroup analysis, a higher incidence of CD combined with uveitis was also observed in IBD patients residing in Europe (RR 1.75, 95% CI 1.37–2.24). Conclusions Data from 115 854 IBD patients showed that CD patients were more likely to suffer from uveitis than UC patients. Ocular manifestations in IBD, particularly CD, warrant greater attention.
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