信号转导
岩石2
岩石1
Rho相关蛋白激酶
生物
GTP酶
罗亚
细胞生物学
小型GTPase
肌动蛋白细胞骨架
激酶
神经科学
细胞骨架
细胞
遗传学
出处
期刊:Neurology
[Ovid Technologies (Wolters Kluwer)]
日期:2023-09-13
卷期号:101 (12): 536-543
被引量:2
标识
DOI:10.1212/wnl.0000000000207779
摘要
Rho-associated coiled-coil containing kinases (ROCK), including ROCK1 and ROCK2, are the primary effectors of the Rho family of small guanosine triphosphatases (GTPases)1 (Figure). The Rho/ROCK signaling pathway has a critical role in regulating the cytoskeleton dynamics responsible for cell adhesion, proliferation, motility, and contraction.2,3 In the nervous system, ROCK proteins phosphorylate a wide variety of transduction molecules that regulate axonal growth during development and after injury; dendritic growth and spine remodeling underlying synaptic plasticity; cell survival through cross talk with other signal transduction pathways; and glial activation and function, including neuroinflammation.4-7 Experimental studies using ROCK antagonists or RNA interference approaches indicate that Rho/ROCK signaling may have a major role in the pathogenesis of a wide range of neurologic and non-neurologic disorders. Not surprisingly, ROCK inhibition has been extensively explored as an emerging therapeutic target in several disease models. There are several comprehensive reviews on these topics.2,3,8-14 Some of the basic concepts on Rho/ROCK signaling, its effects in the nervous system, and its potential implications in the pathogenesis and as a therapeutic target in neurologic disorders, will be briefly emphasized in this study.
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