卟啉
牛血清白蛋白
光敏剂
化学
抗菌活性
超细纤维
生物物理学
细菌
多酚
光热治疗
共价键
戊二醛
灭菌(经济)
药物输送
组合化学
共轭体系
核化学
生物化学
光化学
材料科学
纳米技术
色谱法
有机化学
抗氧化剂
生物
货币经济学
外汇市场
聚合物
经济
遗传学
外汇
作者
Wei-Yu Mu,Zhiqiang Wang,Qiuyun Chen
标识
DOI:10.1016/j.jphotochem.2023.114766
摘要
The emergence of drug-resistant bacteria (DRB) has been a prominent public healthy challenge caused by the overuse of antibiotics. In nature, protein combines with photosensitizer via non-covalent bond forming photo-system for plant protection. Imitation of natural light harvesting system will be efficient materials for sterilization. Here, a photo-responsive microfiber (PCA@BSA) was constructed by the self-assembly of bovine serum albumin (BSA) with the NH2-NH-CO– groups conjugated porphyrin (P) and caffeic acid (CA, a kind of polyphenol). The surface decoration of gold nanoparticles provided the microfibers (PCA@BSA-Au MFs) with photothermal ability and intensive affinity with bacteria. Biological evaluation unveiled excellent photo-driven (808 nm and red LED) antibacterial efficiency. Particularly, CA encapsulated in PCA@BSA-Au MFs could be released by the trigger of acidic environment or active bacteria, resulting in the enhancement of antibacterial effect and a tenuous morphology of PCA@BSA-Au MFs. These results validate the assembly of porphyrin and natural polyphenols templated protein is a novel photosystem toward antisepsis.
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