NAD+激酶
烟酰胺单核苷酸
烟酰胺腺嘌呤二核苷酸
烟酰胺
烟酰胺磷酸核糖转移酶
生物化学
酶
细胞生物学
转移酶
化学
乙酰化
组蛋白
细胞内
生物
DNA
基因
作者
Aihong Peng,Junqin Li,Jianxiao Xing,Yuanjun Yao,Xuping Niu,Kaiming Zhang
标识
DOI:10.3389/fmolb.2024.1480617
摘要
Nicotinamide phosphoribosyl transferase (NAMPT) is a rate-limiting enzyme in the mammalian nicotinamide adenine dinucleotide (NAD) salvage pathway, and plays a vital role in the regulation of cell metabolic activity, reprogramming, aging and apoptosis. NAMPT synthesizes nicotinamide mononucleotide (NMN) through enzymatic action, which is a key protein involved in host defense mechanism and plays an important role in metabolic homeostasis and cell survival. NAMPT is involved in NAD metabolism and maintains intracellular NAD levels. Sirtuins (SIRTs) are a family of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases (HDACs), the members are capable of sensing cellular NAD+ levels. NAMPT-NAD and SIRT constitute a powerful anti-stress defense system. In this paper, the structure, biological function and correlation with diseases of NAMPT are introduced, aiming to provide new ideas for the targeted therapy of related diseases.
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