粘液
子宫内膜
雌激素
透明质酸
微泡
多巴胺
内科学
材料科学
癌症研究
内分泌学
生物
医学
小RNA
生物化学
解剖
生态学
基因
作者
Chenchen Li,Haoyi Jin,Dashi Deng,Chenfan Kong,Lida Feng,Weijing Wang,Kun Lin,Yuqing Li,Qifang Lei,Lisha Liu,Tao Tao,Rui‐Le Pan,Guangzhi Li,Song Wu
标识
DOI:10.1002/adma.202407750
摘要
Abstract Thin endometrium (TE) is closely associated with infertility in reproductive medicine. Estrogen therapy gains unsatisfactory outcomes. In this study, an artificial mucus based on dopamine (L‐DOPA)‐modified hyaluronic acid combining phytoestrogen cajaninstilbene acid and rat urinary exosomes (CUEHD) is constructed for TE treatment using a rat TE model. In the rat TE model, the dominant elastic behavior and adhesive properties of CUEHD guarantee adequate retention, rendering superior synergistic treatment efficacy and favorable biosafety characteristics. CUEHD treatment significantly increases endometrial thickness and promotes receptivity and fertility. Mechanistically, estrogen homeostasis, inflammation inhibition, and endometrial regeneration are achieved through the crosstalk between ER‐NLRP3‐IL1β and Wnt‐β catenin‐TGFβ‐smad signaling pathways. Moreover, the therapeutic potential of exosomes from human urine and adipose tissue‐derived stem cells (ADSCs) and rat ADSCs are also demonstrated, indicating extensive use of the artificial mucus system. Thus, this study illustrates a platform combining phytoestrogen and exosomes with promising implications for TE treatment.
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