A Hand-in-Hand Phenomenon in Older Adults: Increased Risk of Frailty in Geriatric Outpatients Associated with Handgrip Strength Asymmetry and Weakness

Handgrip strength (HGS) is accepted as a predictor of overall health status and a biomarker of aging, besides negative health outcomes and mortality. While differences in HGS between the dominant and non-dominant hands are expected, substantial discrepancies may signal impaired muscle function. This study aims to investigate whether handgrip asymmetry can serve as a reliable indicator of frailty in a diverse population of older adults.