Distribution and Antifungal Susceptibilities of Candida Species Isolated from Blood Cultures from 2016 to 2023 years

The aim of this study was to investigate the distribution and antifungal susceptibilities of Candida spp.from blood culture to provide useful information on empirical treatment of Candidemia.We investigated distribution and antifungal susceptibilities of Candida spp.isolated from blood culture during an 8-years (2016-2023) in a C-University hospital.Over 8 years, 1,182 Candida strains from blood culture were isolated, which was fourth most common cause of bloodstream infection.Among nonduplicated 350 Candida strains, C. albicans was the most common with 45.43%, followed by C. glabrata (17.43%), C. tropicalis (17.43%), C. parapsilosis (14.86%), C. guilliermondii (1.71%), C. krusei (0.86%), C. lusitaniae (0.86%), C. ciferrii (0.57%).In the antifungal susceptibility testing on 323 Candida strains, the non-susceptibility rate was 2.48% for amphotericin B, 1,71% for flucytosine, 3.09% for fluconazole, 4.66% for voriconazole, 5.57% for caspofungin, and 0.62% for micafungin.In particular, C. albicans showed non-susceptibility of 8.23% to voriconazole, and C. glabrata showed 14.81% and 24.59% to fluconazole and caspofungin, respectively.These data showed that the prevalence of candidemia is very common, and antifungal resistance in Candida spp., especially C. glabrata, is increasing.Therefore, periodic surveillance of prevalence and antifungal susceptibility of blood culture is very important for clinical laboratory.