EZH2型
CCL5
T细胞
免疫系统
CD8型
趋化因子
癌症研究
炎症
生物
免疫学
细胞生物学
表观遗传学
白细胞介素2受体
生物化学
基因
作者
Cecilia Assunta Bonfiglio,Michael Lacy,Vasiliki Triantafyllidou,Floriana Maria Farina,Aleksandar Janjic,Katrin Nitz,Yuting Wu,Venetia Bazioti,Irem Avcilar-Kücükgöze,Yonara Freire Soares Marques,Markus Joppich,Mahadia Kumkum,K. Ross,Anuroop Venkateswaran Venkatasubramani,Axel Imhof,Wolfgang Enard,Lars Mäegdefessel,Menno P.J. de Winther,Christian Weber,Donato Santovito
出处
期刊:Circulation
[Lippincott Williams & Wilkins]
日期:2025-02-07
卷期号:151 (19): 1391-1408
被引量:12
标识
DOI:10.1161/circulationaha.124.072384
摘要
Our study uncovers the importance of T cell EZH2 in human and mouse atherosclerosis. Inhibition of Ezh2 in CD4+ T cells drives type 2 immune responses, resulting in an accumulation of iNKT2 and Th2 cells, memory T cells and anti-inflammatory macrophages that limit the progression of atherosclerosis.
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