The Value of LC-MS/MS in Apparent Bilateral Aldosterone Suppression in Adrenal Venous Sampling for Primary Aldosteronism

原发性醛固酮增多症 亚型 醛固酮 医学 免疫分析 内科学 背景(考古学) 醛固酮增多症 胃肠病学 泌尿科 生物 免疫学 抗体 计算机科学 古生物学 程序设计语言
作者
Wei Li,Qixin Zhou,Yifan He,Wenwen He,Ying Song,Jinbo Hu,Yue Wang,Ting Luo,Qifu Li,Shumin Yang,Ying Jing,Yao Zhang,Weiyang He,Yihong He,Wei Cheng,Bin Peng
出处
期刊:The Journal of Clinical Endocrinology and Metabolism [Oxford University Press]
被引量:1
标识
DOI:10.1210/clinem/dgae891
摘要

Abstract Context Adrenal venous sampling (AVS) is recommended for subtyping primary aldosteronism (PA), however, it is unreliable when apparent bilateral aldosterone suppression (ABAS) occurs, defined as aldosterone/cortisol ratio in the adrenal vein being bilaterally lower than that in the inferior vena cava. The value of Liquid chromatography-tandem mass spectrometry (LC-MS/MS) in PA subtyping when ABAS occurs is unclear. Objective To determine whether LC-MS/MS can reduce the occurrence of ABAS and misdiagnosis of PA subtyping. Design, Setting, Participants and Main Outcome Aldosterone and cortisol in AVS samples from 219 patients with PA were measured by LC-MS/MS and immunoassay. Then ABAS occurrence and misdiagnosis rate of PA subtyping were calculated. Results Among 219 patients with PA, 111 and 60 received non-ACTH and ACTH-stimulated AVS, respectively, and 48 received both. In unstimulated AVS, LC-MS/MS reduced the ABAS occurrence compared to immunoassay [10.7% (17/159) vs. 3.1% (5/159)]. Among 159 patients with unstimulated AVS, there were 77 patients who had final subtyping diagnosis based on postoperative outcomes. The misdiagnosis rate of immunoassay and LC-MS/MS was 10.4% (8/77) and 9.1% (7/77), respectively. However, the misdiagnosis were more common in patients with ABAS than in those without ABAS. For immunoassay, five out of six ABAS patients were misdiagnosed, while 3/71 non-ABAS patients were misdiagnosed. For LC MS/MS, only one ABAS patient had follow-up outcome and he was misdiagnosed, while 6/76 non-ABAS patients were misdiagnosed. Similar results were found in ACTH-stimulated AVS. Conclusion LC-MS/MS measurement of aldosterone and cortisol is a new resolution when ABAS occurs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
韦谷兰完成签到,获得积分10
刚刚
22222发布了新的文献求助10
1秒前
cyh发布了新的文献求助10
3秒前
4秒前
Rondab应助loyal采纳,获得10
4秒前
大模型应助韦谷兰采纳,获得10
5秒前
TT完成签到,获得积分10
5秒前
5秒前
英子完成签到,获得积分10
8秒前
科研通AI5应助湛湛采纳,获得10
9秒前
10秒前
10秒前
11秒前
王星星发布了新的文献求助10
11秒前
LaTeXer应助科研通管家采纳,获得50
11秒前
科研通AI2S应助科研通管家采纳,获得10
11秒前
Zhang应助科研通管家采纳,获得10
12秒前
核桃应助科研通管家采纳,获得10
12秒前
小宋同学应助科研通管家采纳,获得10
12秒前
在水一方应助科研通管家采纳,获得10
12秒前
首席医官完成签到,获得积分10
12秒前
情怀应助科研通管家采纳,获得10
12秒前
13秒前
13秒前
14秒前
zyh发布了新的文献求助30
15秒前
15秒前
量子星尘发布了新的文献求助10
16秒前
22发布了新的文献求助10
17秒前
Jasper应助Mark采纳,获得10
18秒前
malele发布了新的文献求助10
19秒前
SciGPT应助王星星采纳,获得10
19秒前
21秒前
hyue发布了新的文献求助10
21秒前
鲤鱼似狮完成签到,获得积分10
22秒前
22秒前
22秒前
orixero应助拼搏的酸奶采纳,获得30
23秒前
小陈发布了新的文献求助10
24秒前
26秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988997
求助须知:如何正确求助?哪些是违规求助? 3531351
关于积分的说明 11253520
捐赠科研通 3269928
什么是DOI,文献DOI怎么找? 1804830
邀请新用户注册赠送积分活动 882063
科研通“疑难数据库(出版商)”最低求助积分说明 809068