纤维化
细胞外基质
巨噬细胞
肝纤维化
肝星状细胞
肝纤维化
免疫系统
医学
癌症研究
病态的
免疫学
病理
生物
细胞生物学
生物化学
体外
作者
Jun Ran,Shengxia Yin,Rahma Issa,Qianwen Zhao,Guangqi Zhu,Huan Zhang,Qun Zhang,Chao Wu,Jie Li
标识
DOI:10.1097/hc9.0000000000000602
摘要
Liver fibrosis is a pathological change characterized by excessive deposition of extracellular matrix caused by chronic liver injury, and the mechanisms underlying its development are associated with endothelial cell injury, inflammatory immune cell activation, and HSC activation. Furthermore, hepatic macrophages exhibit remarkable heterogeneity and hold central functions in the evolution of liver fibrosis, with different subgroups exerting dual effects of promotion and regression. Currently, targeted macrophage therapy for reversing hepatic fibrosis has been extensively studied and has shown promising prospects. In this review, we will discuss the dual role of macrophages in liver fibrosis and provide new insights into reversing liver fibrosis based on macrophages.
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