Reinforcement Learning is Impaired in the Sub-acute Post-stroke Period

神经康复 运动学习 康复 钢筋 心理学 冲程(发动机) 物理医学与康复 运动技能 神经可塑性 强化学习 认知 听力学 医学 发展心理学 神经科学 机器学习 机械工程 社会心理学 计算机科学 工程类
作者
Meret Branscheidt,Alkis M. Hadjiosif,Manuel A. Anaya,Jennifer Keller,Mario Widmer,Keith D. Runnalls,Andreas R. Luft,Amy J. Bastian,John W. Krakauer,Pablo Celnik
出处
期刊:Neurorehabilitation and Neural Repair [SAGE]
标识
DOI:10.1177/15459683241304352
摘要

Background: In humans, most spontaneous recovery from motor impairment after stroke occurs in the first 3 months. Studies in animal models show higher responsiveness to training over a similar time-period. Both phenomena are often attributed to a milieu of heightened plasticity, which may share some mechanistic overlap with plasticity associated with normal motor learning. Objective: Given that neurorehabilitation approaches are frequently predicated on motor learning principles, here we asked if the sensitivity of trial-to-trial learning for 2 kinds of motor learning processes often involved during rehabilitation is also enhanced early post-stroke. In a cross-sectional design, we compared (1) reinforcement and (2) error-based learning in 2 groups: 1 tested within 3 months after stroke (early group, N = 35) another tested more than 6 months after stroke (late group, N = 30). These 2 forms of motor learning were assessed with variations of the same visuomotor rotation task. Critically, motor execution was matched between the 2 groups. Results: Reinforcement learning was impaired in the early but not the late group, whereas error-based learning was unimpaired in either group. These findings could not be attributed to differences in baseline execution, cognitive impairment, gender, age, or lesion volume and location. Discussion: The presence of a deficit in reinforcement motor learning in the first 3 months after stroke has important implications for rehabilitation. Conclusion: It might be necessary to either increase reinforcement feedback given early after stroke, increase the dose of rehabilitation to compensate, or delay onset of rehabilitation approaches that may rely on reinforcement, for example, constraint-induced movement therapy, and instead emphasize other forms of motor training in the subacute time period.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
11111111发布了新的文献求助10
1秒前
1秒前
科目三应助ccccccc采纳,获得30
1秒前
William_l_c完成签到,获得积分10
3秒前
换胃思考发布了新的文献求助10
4秒前
4秒前
7秒前
下雨了完成签到,获得积分10
8秒前
9秒前
老木虫发布了新的文献求助10
9秒前
10秒前
和谐的孱完成签到,获得积分10
10秒前
小虎发布了新的文献求助10
12秒前
逗乐发布了新的文献求助10
13秒前
流浪发布了新的文献求助10
14秒前
15秒前
李叉叉完成签到 ,获得积分10
15秒前
小白完成签到,获得积分10
17秒前
AA完成签到,获得积分10
19秒前
科研通AI5应助liziming采纳,获得10
20秒前
论文狗发布了新的文献求助10
20秒前
乐乐应助lyy采纳,获得10
21秒前
L1关注了科研通微信公众号
22秒前
Geodada完成签到,获得积分10
22秒前
Wei完成签到 ,获得积分10
23秒前
zym完成签到,获得积分10
24秒前
25秒前
meini完成签到 ,获得积分10
26秒前
捏捏捏完成签到 ,获得积分10
27秒前
星辰大海应助qixinyi采纳,获得10
28秒前
29秒前
29秒前
流浪完成签到,获得积分10
29秒前
29秒前
liziming发布了新的文献求助10
30秒前
TIGun发布了新的文献求助10
33秒前
re发布了新的文献求助10
34秒前
35秒前
落寞的忆之完成签到,获得积分20
35秒前
panpanliumin完成签到,获得积分0
35秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
Exploring the effects of an evidenced-based professional development programme on teaching and learning in Chinese kindergartens 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3576634
求助须知:如何正确求助?哪些是违规求助? 3146582
关于积分的说明 9465813
捐赠科研通 2848133
什么是DOI,文献DOI怎么找? 1565465
邀请新用户注册赠送积分活动 733041
科研通“疑难数据库(出版商)”最低求助积分说明 719546