抗体调理
抗体
同型
生物
登革热病毒
病毒学
微生物学
免疫球蛋白G
吞噬作用
免疫学
登革热
调理素
单克隆抗体
作者
Mitchell J Waldran,Adam D. Wegman,Lauren E. Bahr,Nathan H. Roy,Jeffrey R. Currier,Adam T. Waickman
标识
DOI:10.1093/infdis/jiad122
摘要
Abstract Dengue virus (DENV) is endemic in >100 countries, infecting an estimated 400 million individuals every year. Infection with DENV raises an antibody response primarily targeting viral structural proteins. However, DENV encodes several immunogenic nonstructural (NS) proteins, one of which, NS1, is expressed on the membrane of DENV-infected cells. IgG and IgA isotype antibodies that bind NS1 are abundant in serum following DENV infection. Our study aimed to determine if NS1-binding IgG and IgA isotype antibodies contribute to the clearance of DENV-infected cells by antibody-mediated cellular phagocytosis. We observed that both IgG and IgA isotype antibodies can facilitate monocytic uptake of DENV NS1-expressing cells in an FcγRI- and FcαRI-dependent fashion. Interestingly, this process was antagonized by the presence of soluble NS1, suggesting that the production of soluble NS1 by infected cells may serve as immunological chaff, antagonizing opsonization and clearance of DENV-infected cells.
科研通智能强力驱动
Strongly Powered by AbleSci AI