Bioartificial liver with reprogrammed hepatocytes ready for prime time

In this issue, Wang et al. 1 Wang Y. Zheng Q. Sun Z. Wang C. Cen J. Zhang X. Jin Y. Wu B. Yan T. Wang Z. et al. Reversal of post-hepatectomy liver failure using a bioartificial liver supporting system implanted with clinical-grade human induced hepatocytes. Cell Stem Cell. 2023; 30: 617-631 Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar provide evidence of the pre-clinical as well as the clinical utility of in vitro-generated directly reprogrammed human hepatocytes in bioartificial liver. This approach will help offer patients a more curative surgical therapy for liver cancer and improve survival rates. In this issue, Wang et al. 1 Wang Y. Zheng Q. Sun Z. Wang C. Cen J. Zhang X. Jin Y. Wu B. Yan T. Wang Z. et al. Reversal of post-hepatectomy liver failure using a bioartificial liver supporting system implanted with clinical-grade human induced hepatocytes. Cell Stem Cell. 2023; 30: 617-631 Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar provide evidence of the pre-clinical as well as the clinical utility of in vitro-generated directly reprogrammed human hepatocytes in bioartificial liver. This approach will help offer patients a more curative surgical therapy for liver cancer and improve survival rates.