Single-cell transcriptome analysis reveals interaction between CCL19+ inflammatory keratinocytes and CCR7+ dendritic cells and B cells in pemphigus

Pemphigus is a complex autoimmune skin disorder, with an incidence of 0.6-32 per million annually ( Kasperkiewicz et al., 2017 Kasperkiewicz M. Ellebrecht C.T. Takahashi H. Yamagami J. Zillikens D. Payne A.S. et al. Pemphigus. Nat Rev Dis Primers. 2017; 317026 Crossref PubMed Scopus (335) Google Scholar ). The central role of B cell dysfunction in pemphigus is established, but the contributions of other cells are still not well defined and are difficult to elucidate using conventional approaches. The availability of single-cell RNA sequencing (scRNA-seq) provides an excellent opportunity to explore these questions.