医学
睡眠(系统调用)
病理生理学
疾病
肝病
慢性肝病
病因学
睡眠障碍
内科学
肝硬化
精神科
失眠症
计算机科学
操作系统
作者
Bradley Busebee,Kymberly D. Watt,Kara Dupuy-McCauley,Hilary M. DuBrock
标识
DOI:10.1097/lvt.0000000000000369
摘要
Sleep disturbances are common in chronic liver disease and significantly impact patient outcomes and quality of life. The severity and nature of sleep disturbances vary by liver disease etiology and severity. While there is ongoing research into the association between liver disease and sleep-wake dysfunction, the underlying pathophysiology varies and, in many cases, is poorly understood. Liver disease is associated with alterations in thermoregulation, inflammation, and physical activity, and is associated with disease-specific complications, such as HE, that may directly affect sleep. In this article, we review the relevant pathophysiologic processes, disease-specific sleep-wake disturbances, and clinical management of CLD-associated sleep-wake disturbances.
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