胶质瘤
小胶质细胞
肿瘤微环境
免疫系统
生物
调节器
癌变
癌症研究
表型
肿瘤进展
神经科学
巨噬细胞
免疫学
癌症
炎症
遗传学
体外
基因
作者
Yuting Deng,Qin-Yan Chen,Chao Wan,Yajie Sun,Fang Huang,Yan H,Kunyu Yang
标识
DOI:10.1186/s13578-024-01231-7
摘要
Abstract Reciprocal interactions between the tumor microenvironment (TME) and cancer cells play important roles in tumorigenesis and progression of glioma. Glioma-associated macrophages (GAMs), either of peripheral origin or representing brain-intrinsic microglia, are the majority population of infiltrating immune cells in glioma. GAMs, usually classified into M1 and M2 phenotypes, have remarkable plasticity and regulate tumor progression through different metabolic pathways. Recently, research efforts have increasingly focused on GAMs metabolism as potential targets for glioma therapy. This review aims to delineate the metabolic characteristics of GAMs within the TME and provide a summary of current therapeutic strategies targeting GAMs metabolism in glioma. The goal is to provide novel insights and therapeutic pathways for glioma by highlighting the significance of GAMs metabolism.
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