光热治疗
光动力疗法
光敏剂
发光
癌细胞
纳米点
纳米技术
癌症
渗透(战争)
光热效应
活性氧
纳米颗粒
生物物理学
化学
材料科学
癌症研究
医学
光化学
光电子学
生物
生物化学
内科学
有机化学
工程类
运筹学
作者
Zhanlin Zhang,Tian Xia,Pan Ran,Junwu Wei,Jie Meng,Guiyuan Zhang,Xiaohong Li
标识
DOI:10.1016/j.cej.2022.141226
摘要
Cancer photothermal (PTT) and photodynamic therapies (PDT) have aroused tremendous attention with high spatial specificity, but they experience the challenges from the inefficient tumor accumulation and penetration of photosensitizers and dose-dependent side effects. Herein, persistent luminescence (PL)-activated nanomotors are developed with the integration of PL-illuminated PTT and PDT to overcome these limitations. PL nanodots of ZnGa2O4:Cr3+ (ZGC) were deposited on mesoporous silica nanoparticles (NPs), followed by conjugation of silicon phthalocyanine as a photosensitizer and capping with polydopamine (PDA) to fabricate Janus [email protected] NPs. ZGC nanodots on NPs are activated by external illumination to generate PL as an internal light source to excite PDA and phthalocyanine for persistent productions of heat and reactive oxygen species (ROS), avoiding high heat stress and ROS levels in the conventional intermittent phototherapy. In addition, the persistent heat gradients around the Janus NPs create thermophoretic force to drive their motions and enhance their cellular uptake, and the PL-illuminated PDT continuously produces intracellular ROS to damage tumor cells. Light activation of [email protected] obviously promotes accumulation and deep penetration of NPs into tumors and produces mild thermal and ROS levels with well distribution across the tumors. The self-propelled tumor distribution and the combined PDT/PTT treatment led to full inhibition of tumor growth and significant extension of animal survival, and there is no systemic toxicity and function fluctuation of the major organs. Thus, this study demonstrates a concise strategy to generate PL-activated motion for deep penetration and produce PL-illuminated PDT/PTT for synergistic tumor treatment.
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