A Computed Tomography-based Radiomics Nomogram for Predicting Osteoporotic Vertebral Fractures: A Longitudinal Study

列线图 医学 接收机工作特性 骨质疏松症 置信区间 定量计算机断层扫描 曲线下面积 危险系数 内科学 核医学 比例危险模型 放射科 骨密度
作者
Miaomiao Wang,Xin Chen,Wenjing Cui,Xinru Wang,Nandong Hu,Hongye Tang,Chao Zhang,Jirong Shen,Chao Xie,Xiao Chen
出处
期刊:The Journal of Clinical Endocrinology and Metabolism [Oxford University Press]
卷期号:108 (6): e283-e294 被引量:10
标识
DOI:10.1210/clinem/dgac722
摘要

Abstract Context Fractures are a serious consequence of osteoporosis in older adults. However, few longitudinal studies have shown the role of computed tomography (CT)-based radiomics in predicting osteoporotic fractures. Objective We evaluated the performance of a CT radiomics-based model for osteoporotic vertebral fractures (OVFs) in a longitudinal study. Methods A total of 7906 individuals without OVF older than 50 years, and who underwent CT scans between 2016 and 2019 were enrolled and followed up until 2021. Seventy-two cases of new OVF were identified. A total of 144 people without OVF during follow-up were selected as controls. Radiomics features were extracted from baseline CT images. CT values of trabecular bone, and area and density of erector spinae were determined. Cox regression analysis was used to identify the independent associated factors. The predictive performance of the nomogram was assessed using the receiver operating characteristic curve, calibration curve, and decision curve. Results CT value of vertebra (adjusted hazard ratio (aHR) = 2.04; 95% CI, 1.07-3.89), radiomics score (aHR = 6.56; 95% CI, 3.47-12.38), and area of erector spinae (aHR = 1.68; 95% CI, 1.02-2.78) were independently associated with OVF. Radscore was associated with severe OVF (aHR = 6.00; 95% CI, 2.78-12.93). The nomogram showed good discrimination with a C-index of 0.82 (95% CI, 0.77-0.87). The area under the curve of nomogram and radscore were both higher than osteoporosis + muscle area for 3-year and 4-year risk of fractures (P < .05). The decision curve also demonstrated that the radiomics nomogram was useful. Conclusion Bone radiomics is associated with OVF, and the nomogram based on radiomics signature and muscle provides a tool for the prediction of OVF.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
西瓜完成签到 ,获得积分10
刚刚
小张完成签到,获得积分10
1秒前
EVEN发布了新的文献求助30
2秒前
王冉冉发布了新的文献求助10
2秒前
2秒前
研无止境w发布了新的文献求助10
3秒前
5秒前
奶油泡fu完成签到 ,获得积分10
5秒前
dong东包完成签到,获得积分20
6秒前
6秒前
ED应助cccccc采纳,获得10
6秒前
shangziru发布了新的文献求助10
7秒前
漠之梦完成签到,获得积分20
8秒前
sc完成签到,获得积分10
8秒前
谦让的含海完成签到,获得积分10
8秒前
好运連連完成签到,获得积分10
9秒前
11秒前
liu完成签到,获得积分10
11秒前
飞翔的霸天哥应助Yuanchaoyi采纳,获得30
12秒前
香蕉觅云应助WJH采纳,获得10
13秒前
汉堡包应助研友_LOoomL采纳,获得10
13秒前
小二郎应助Felix采纳,获得10
13秒前
zaphkiel完成签到 ,获得积分10
14秒前
健壮的囧完成签到,获得积分10
15秒前
torch132完成签到,获得积分10
16秒前
桐桐应助阿景采纳,获得10
17秒前
17秒前
震动的平松完成签到 ,获得积分10
17秒前
Ting完成签到 ,获得积分10
18秒前
18秒前
Hello应助王冉冉采纳,获得30
19秒前
Ava应助Jarvi采纳,获得10
19秒前
20秒前
21秒前
22秒前
一枚研究僧完成签到,获得积分0
22秒前
22秒前
赘婿应助科研通管家采纳,获得10
23秒前
英姑应助科研通管家采纳,获得10
23秒前
思源应助科研通管家采纳,获得10
23秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038569
求助须知:如何正确求助?哪些是违规求助? 3576279
关于积分的说明 11374944
捐赠科研通 3305979
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815048