化学
表面改性
肟
结合
天然产物
芳基
组合化学
功能群
有机化学
聚合物
数学
数学分析
物理化学
烷基
作者
Harpreet Kour,Alpa Sharma,Jaspreet Kour,Mukhtar Ahmed,Sanghapal D. Sawant
标识
DOI:10.1002/ejoc.202201375
摘要
Abstract A simple, metal‐free, and green approach has been established for N−H functionalization of sulfoximines under mild reaction conditions to offer sulfoximinated‐oxime conjugates. The reaction works well in EtOH at room temperature and proceeds smoothly without using any base or expensive ligands. This protocol has been applied on various aryl‐, heteroaryl‐ sulfoximines as well as on variety of chloro‐oximes. Both the substrates tolerated a wide range of functional groups, resulting in good to excellent yields. It can serve as a directing group in organic synthesis, as a precursor or building block, demonstrating the product's applicability and importance in the field. The applications of the protocol have been demonstrated in the sulfoximination of some natural products. This strategy could be useful in drug discovery or medicinal chemistry for fine‐tuning the physicochemical properties of natural product scaffolds or lead candidates.
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