Effects of Ficus carica paste on loperamide-induced constipation in rats

洛哌丁胺 便秘 加勒比 医学 粪便 内科学 盲肠 胃肠病学 动物科学 胃动素 地穴 回肠 体重 腹泻 生物 植物 古生物学
作者
Hak-Yong Lee,Jung‐Hoon Kim,Han-Wool Jeung,Cha-Uk Lee,Do‐Sung Kim,Bo Li,Geum‐Hwa Lee,Myung-Soon Sung,Ki-Chan Ha,Hyang‐Im Back,Min Sun Kim,Soo-Hyun Park,Mi‐Ra Oh,Min‐Gul Kim,Ji‐Young Jeon,Yong‐Jin Im,Minho Hwang,Byung‐Ok So,Sook‐Jeong Shin,Wan‐Hee Yoo,Hyung‐Ryong Kim,Han‐Jung Chae,Soo‐Wan Chae
出处
期刊:Food and Chemical Toxicology [Elsevier]
卷期号:50 (3-4): 895-902 被引量:90
标识
DOI:10.1016/j.fct.2011.12.001
摘要

Constipation is one of the most common gastrointestinal complaints worldwide. This study examined the effects of fig (Ficus carica L.) paste for the treatment of loperamide-induced constipation in a rat model.Animals were divided into one normal control group and four experimental groups (0, 1, 6, and 30 g/kg). Loperamide (2 mg/kg, twice per day) was injected intraperitoneally to induce constipation in the four experimental groups. Fig paste was administered for 4 weeks to assess its anti-constipation effects.Fecal pellet number, weight and water content were increased in the fig-treated groups as compared to the control group. Reductions in body weight and increased intestinal transit length were observed in the fig-treated groups. Fecal pellet number was reduced in the distal colons of the fig-treated rats. Exercise and ileum tension increased in the experimental groups as compared to the control group. According to histological analyses, the thickness of the distal colon and areas of crypt epithelial cells that produce mucin were increased in the fig-treated groups in a dose-dependent manner.Constipation was decreased when fig fruit was fed to rats. Specifically, fecal number, weight, and water content, as well as histological parameters such as thickness and mucin areas in the distal colon were improved. Fig treatment may be a useful therapeutic and preventive strategy for chronic constipation.
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