谵妄
脑电图
四分位间距
医学
麻醉
心脏病学
内科学
重症监护医学
精神科
作者
Edwin van Dellen,Arendina W. van der Kooi,Tianne Numan,Huiberdina L. Koek,Francina A M Klijn,Marc P. Buijsrogge,Cornelis J. Stam,Arjen J. C. Slooter
出处
期刊:Anesthesiology
[Ovid Technologies (Wolters Kluwer)]
日期:2014-08-01
卷期号:121 (2): 328-335
被引量:87
标识
DOI:10.1097/aln.0000000000000329
摘要
Abstract Background: In this article, the authors explore functional connectivity and network topology in electroencephalography recordings of patients with delirium after cardiac surgery, aiming to improve the understanding of the pathophysiology and phenomenology of delirium. The authors hypothesize that disturbances in attention and consciousness in delirium may be related to alterations in functional neural interactions. Methods: Electroencephalography recordings were obtained in postcardiac surgery patients with delirium (N = 25) and without delirium (N = 24). The authors analyzed unbiased functional connectivity of electroencephalography time series using the phase lag index, directed phase lag index, and functional brain network topology using graph analysis. Results: The mean phase lag index was lower in the α band (8 to 13 Hz) in patients with delirium (median, 0.120; interquartile range, 0.113 to 0.138) than in patients without delirium (median, 0.140; interquartile range, 0.129 to 0.168; P < 0.01). Network topology in delirium patients was characterized by lower normalized weighted shortest path lengths in the α band (t = −2.65; P = 0.01). δ Band–directed phase lag index was lower in anterior regions and higher in central regions in delirium patients than in nondelirium patients (F = 4.53; P = 0.04, and F = 7.65; P < 0.01, respectively). Conclusions: Loss of α band functional connectivity, decreased path length, and increased δ band connectivity directed to frontal regions characterize the electroencephalography during delirium after cardiac surgery. These findings may explain why information processing is disturbed in delirium.
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