乙酰胆碱
神经递质
化学
神经肌肉接头
神经传递
神经科学
生物物理学
拉曼散射
拉曼光谱
中枢神经系统
生物化学
内分泌学
生物
物理
光学
受体
作者
Dan Fu,Wenlong Yang,X. Sunney Xie
摘要
Acetylcholine is an important neurotransmitter that relays neural excitation from lower motor neurons to muscles. It also plays significant roles in the central nervous system by modulating neurotransmission. However, there is a lack of tools to directly measure the quantity and distribution of acetylcholine at the subcellular level. In this Communication, we demonstrate for the first time that label-free imaging of acetylcholine is achieved with frequency-modulated spectral-focusing stimulated Raman scattering (FMSF-SRS) microscopy: a technical improvement over traditional SRS microscopy that effectively removes imaging backgrounds. Moreover, we directly quantified the local concentration of acetylcholine at the neuromuscular junction of frog cutaneous pectoris muscle.
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