区域选择性
化学
大气(单位)
催化作用
胺气处理
氩
有机化学
光化学
热力学
物理
作者
Wesley Zongrong Yu,Cheng Yi,Ming Wah Wong,Ying‐Yeung Yeung
标识
DOI:10.1002/adsc.201600821
摘要
A complete switch of regioselectivity in the aminobromination of olefins is realized from delicate changes in the reaction temperature from 25 °C to 40 °C and the atmosphere from air to argon, under catalyst-free conditions. The resulting α-bromoamides can be transformed easily to high-value compounds (e.g., Clobenzorex). Mechanistic studies revealed that the reaction went through a radical pathway governed by in-situ generated bromo(tosyl)amine (TsNHBr).
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